Feb 19, · Diazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms and stiffness. Diazepam is sometimes used with other medications to treat danhaigh.com name: Valium. Oct 13, · Diazepam is used to treat anxiety, alcohol withdrawal, muscle spasms, and certain types of seizure.
Diazepam is a benzodiazepine ben-zoe-dye-AZE-eh-peen that is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms and stiffness. Diazepam is sometimes used with other medications to treat seizures. Diazepam may also be used diazeppam purposes not listed in this medication guide.
You should not use diazepam what is the time in germany right now you are allergic to it, or if you have:.
Diazepam should not be given to a child younger than 6 months old. Do not give this medicine to a child without a doctor's advice. Some people have thoughts about suicide while taking diazepam. Stay alert to changes in your mood or symptoms.
Report any new or worsening symptoms to your doctor. Do not start or stop taking diazepam to treat seizures during djazepam without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.
When treating anxiety, alcohol withdrawal, or muscle spasms: If diaazepam use diazepam while you are pregnant, your baby could how to ask god for forgiveness for sins dependent on the drug.
This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on us medicine may need medical treatment for several weeks. Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Diazepam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have weak or shallow breathing, if you are hard to wake up, or if you stop breathing.
The sedative effects of diazepam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking diazepam. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Grapefruit may interact with diazepam and lead to unwanted side effects. Avoid the use of grapefruit products.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Use Diazepam Valium exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label and read all medication guides.
Your doctor may occasionally fiazepam your dose. Never use us in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine. Never share this medicine with another person, especially someone with a history of drug abuse or addiction.
Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. Diazepam should be used for only a short time. Do not take this medicine for longer than 4 months without your doctor's advice. Do not stop using diazepam suddenlyeven if you feel fine.
Stopping suddenly may cause increased seizures or unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, diazpam light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.
2mf the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Overdose symptoms diazeppam include extreme drowsiness, loss of balance or coordination, limp or weak muscles, slow breathing, or coma. Health Topics. Health Tools. Diazepam Valium. Last Updated: June 23, You should not diszepam diazepam if you are allergic to it, or if you have: myasthenia gravis a muscle weakness disorder ; a severe breathing problem; sleep how to replace electric pto clutch breathing stops during sleep ; narrow-angle glaucoma; untreated or uncontrolled open-angle glaucoma; or severe liver disease.
Tell your doctor if you have ever had: breathing problems; glaucoma; kidney or liver disease; seizures unless you are taking diazepam to treat a seizure disorder ; a drug or alcohol addiction; or idazepam, a mood disorder, or suicidal whaat or behavior.
Do not breastfeed while using this medicine. Side Effects. Side Effects What are the side effects of Diazepam Valium? Call your doctor at once if you have: severe drowsiness or dizziness; unusual changes in mood or behavior; new or worsening symptoms of depression or anxiety; thoughts of suicide or hurting yourself; confusion, hallucinations, sleep problems; or new or worsening seizures.
Common side effects may include: drowsiness; feeling tired; muscle weakness; or problems with balance or muscle movement. Interactions What drugs and food should I avoid while taking Diazepam Valium?
Avoid wwhat alcohol. Dangerous side effects or death could occur. What should I do if I missed a dose 2mv Diazepam Valium? If you think you or someone else may have flr on: Diazepam Valiumcall your doctor diqzepam the Poison Control center. If someone collapses or isn't breathing after taking Diazepam Valiumcall Z10 Color : blue Shape : round Imprint : Z See More.
Medical Disclaimer Drugs A-Z provides drug 2mv from Everyday Health riazepam our partners, as well as ratings from diazepwm members, all in one place. The information within all other sections is proprietary to Everyday Health. Read more.
Usual Adult Dose for Alcohol Withdrawal
Aug 03, · Diazepam is available for oral administration as tablets containing 2 mg, 5 mg or 10 mg Diazepam. In addition to the active ingredient Diazepam, each tablet contains the following inactive ingredients: anhydrous lactose, magnesium stearate and microcrystalline cellulose. Diazepamis used to treat anxiety, alcohol withdrawal, and seizures. It is also used to relieve muscle spasmsand to provide sedation before medical procedures. This medicationworks by calming the. May 21, · Valium 2 MG Tablet is an anticonvulsant medicine, which is used to relieve the symptoms of seizures, anxiety, muscle spasm, and alcohol withdrawal. This medicine may increase the risk of habit-forming tendency if taken for a long duration or at larger doses.
Medically reviewed by Drugs. Last updated on March 1, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death see Drug Interactions. Diazepam is a benzodiazepine derivative. The chemical name of Diazepam is 7-chloro-1,3-dihydromethylphenyl-2H-1,4-benzodiazepinone.
It is a colorless to light yellow crystalline compound, insoluble in water. The structural formula is as follows:. Diazepam is available for oral administration as tablets containing 2 mg, 5 mg or 10 mg Diazepam. In addition to the active ingredient Diazepam, each tablet contains the following inactive ingredients: anhydrous lactose, magnesium stearate and microcrystalline cellulose.
Diazepam is a benzodiazepine that exerts anxiolytic, sedative, muscle-relaxant, anticonvulsant and amnestic effects. Most of these effects are thought to result from a facilitation of the action of gamma aminobutyric acid GABA , an inhibitory neurotransmitter in the central nervous system. Absorption is delayed and decreased when administered with a moderate fat meal. In the presence of food mean lag times are approximately 45 minutes as compared with 15 minutes when fasting.
There is also an increase in the average time to achieve peak concentrations to about 2. Diazepam and its metabolites cross the blood-brain and placental barriers and are also found in breast milk in concentrations approximately one tenth of those in maternal plasma days 3 to 9 post-partum.
In young healthy males, the volume of distribution at steady-state is 0. The decline in the plasma concentration-time profile after oral administration is biphasic. N-desmethylDiazepam and temazepam are both further metabolized to oxazepam. Temazepam and oxazepam are largely eliminated by glucuronidation.
The initial distribution phase is followed by a prolonged terminal elimination phase half-life up to 48 hours. The terminal elimination half-life of the active metabolite N-desmethylDiazepam is up to hours. Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates. Diazepam accumulates upon multiple dosing and there is some evidence that the terminal elimination half-life is slightly prolonged. In children 3 - 8 years old the mean half-life of Diazepam has been reported to be 18 hours.
In full term infants, elimination half-lives around 30 hours have been reported, with a longer average half-life of 54 hours reported in premature infants of 28 - 34 weeks gestational age and 8 - 81 days post-partum. In both premature and full term infants the active metabolite desmethylDiazepam shows evidence of continued accumulation compared to children.
Longer half-lives in infants may be due to incomplete maturation of metabolic pathways. Elimination half-life increases by approximately 1 hour for each year of age beginning with a half-life of 20 hours at 20 years of age. This appears to be due to an increase in volume of distribution with age and a decrease in clearance. Consequently, the elderly may have lower peak concentrations, and on multiple dosing higher trough concentrations. It will also take longer to reach steady-state. Conflicting information has been published on changes of plasma protein binding in the elderly.
Reported changes in free drug may be due to significant decreases in plasma proteins due to causes other than simply aging. In mild and moderate cirrhosis, average half-life is increased. The average increase has been variously reported from 2-fold to 5-fold, with individual half-lives over hours reported. There is also an increase in volume of distribution, and average clearance decreases by almost half.
Mean half-life is also prolonged with hepatic fibrosis to 90 hours range 66 - hours , with chronic active hepatitis to 60 hours range 26 - 76 hours , and with acute viral hepatitis to 74 hours range 49 - In chronic active hepatitis, clearance is decreased by almost half.
Diazepam Tablets USP are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. In acute alcohol withdrawal, Diazepam may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology such as inflammation of the muscles or joints, or secondary to trauma ; spasticity caused by upper motor neuron disorders such as cerebral palsy and paraplegia ; athetosis; and stiff-man syndrome.
Oral Diazepam may be used adjunctively in convulsive disorders, although it has not proved useful as the sole therapy. The effectiveness of Diazepam in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient. Diazepam Tablets USP are contraindicated in patients with a known hypersensitivity to this drug and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age.
Diazepam is also contraindicated in patients with myasthenia gravis, severe respiratory insufficiency, severe hepatic insufficiency, and sleep apnea syndrome. It may be used in patients with open-angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute narrow-angle glaucoma.
Concomitant use of benzodiazepines, including Diazepam tablets, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone.
If a decision is made to prescribe Diazepam tablets concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. In patients already receiving an opioid analgesic, prescribe a lower initial dose of Diazepam tablets than indicated in the absence of an opioid and titrate based on clinical response.
If an opioid is initiated in a patient already taking Diazepam tablets, prescribe a lower initial dose of the opioid and titrate based upon clinical response. Advise both patients and caregivers about the risks of respiratory depression and sedation when Diazepam tablets are used with opioids. Advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined see Drug Interactions.
Diazepam is not recommended in the treatment of psychotic patients and should not be employed instead of appropriate treatment. Since Diazepam has a central nervous system depressant effect, patients should be advised against the simultaneous ingestion of alcohol and other CNS-depressant drugs during Diazepam therapy. An increased risk of congenital malformations and other developmental abnormalities associated with the use of benzodiazepine drugs during pregnancy has been suggested.
There may also be non-teratogenic risks associated with the use of benzodiazepines during pregnancy. There have been reports of neonatal flaccidity, respiratory and feeding difficulties, and hypothermia in children born to mothers who have been receiving benzodiazepines late in pregnancy.
In addition, children born to mothers receiving benzodiazepines on a regular basis late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period. Cleft palate and encephalopathy are the most common and consistently reported malformations produced in these species by administration of high, maternally toxic doses of Diazepam during organogenesis.
Rodent studies have indicated that prenatal exposure to Diazepam doses similar to those used clinically can produce long-term changes in cellular immune responses, brain neurochemistry, and behavior. In general, the use of Diazepam in women of childbearing potential, and more specifically during known pregnancy, should be considered only when the clinical situation warrants the risk to the fetus. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered.
If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Patients should also be advised that if they become pregnant during therapy or intend to become pregnant they should communicate with their physician about the desirability of discontinuing the drug.
Special care must be taken when Diazepam is used during labor and delivery, as high single doses may produce irregularities in the fetal heart rate and hypotonia, poor sucking, hypothermia, and moderate respiratory depression in the neonates.
With newborn infants it must be remembered that the enzyme system involved in the breakdown of the drug is not yet fully developed especially in premature infants. Diazepam passes into breast milk. Breastfeeding is therefore not recommended in patients receiving Diazepam. If Diazepam is to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be employed - particularly with known compounds that may potentiate the action of Diazepam, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants see Drug Interactions.
The usual precautions are indicated for severely depressed patients or those in whom there is any evidence of latent depression or anxiety associated with depression, particularly the recognition that suicidal tendencies may be present and protective measures may be necessary.
Should this occur, use of the drug should be discontinued. These reactions are more likely to occur in children and the elderly. A lower dose is recommended for patients with chronic respiratory insufficiency, due to the risk of respiratory depression. In debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation 2 mg to 2.
Some loss of response to the effects of benzodiazepines may develop after repeated use of Diazepam for a prolonged time. To assure the safe and effective use of benzodiazepines, patients should be informed that, since benzodiazepines may produce psychological and physical dependence, it is advisable that they consult with their physician before either increasing the dose or abruptly discontinuing this drug.
The risk of dependence increases with duration of treatment; it is also greater in patients with a history of alcohol or drug abuse. Patients should be advised against the simultaneous ingestion of alcohol and other CNS-depressant drugs during Diazepam therapy. As is true of most CNS-acting drugs, patients receiving Diazepam should be cautioned against engaging in hazardous occupations requiring complete mental alertness, such as operating machinery or driving a motor vehicle.
The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists.
Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation. Concomitant use with alcohol is not recommended due to enhancement of the sedative effect. However, there is no effect on the extent of absorption.
The lower peak concentrations appear due to a slower rate of absorption, with the time required to achieve peak concentrations on average 20 - 25 minutes greater in the presence of antacids. However, this difference was not statistically significant.
There is a potentially relevant interaction between Diazepam and compounds which inhibit certain hepatic enzymes particularly cytochrome P 3A and 2C Data indicate that these compounds influence the pharmacokinetics of Diazepam and may lead to increased and prolonged sedation.
At present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole. There have also been reports that the metabolic elimination of phenytoin is decreased by Diazepam.
The data currently available are inadequate to determine the mutagenic potential of Diazepam. Safety and effectiveness in pediatric patients below the age of 6 months have not been established.
In elderly patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation 2 mg to 2. Extensive accumulation of Diazepam and its major metabolite, desmethylDiazepam, has been noted following chronic administration of Diazepam in healthy elderly male subjects. Metabolites of this drug are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function.